And the winner is... Stylet!

src/Artemis.UI/ViewModels/RootViewModel.cs

@@ -0,0 +1,18 @@
+using System.Collections.Generic;
+using System.Linq;
+using Artemis.UI.ViewModels.Interfaces;
+using Stylet;
+
+namespace Artemis.UI.ViewModels
+{
+    public class RootViewModel : Conductor<IArtemisViewModel>.Collection.OneActive
+    {
+        public RootViewModel(ICollection<IArtemisViewModel> artemisViewModels)
+        {
+            // Add the built-in items
+            Items.AddRange(artemisViewModels);
+            // Activate the home item
+            ActiveItem = artemisViewModels.First(v => v.GetType() == typeof(HomeViewModel));
+        }
+    }
+}